sparsentan will lower the level or effect of modafinil by affecting hepatic enzyme CYP2C19 metabolism. Use Warning/Watch. Sparsentan (a CYP2C19 inducer) decreases exposure of CYP2C19 substrates and minimizes efficacy associated with these substrates. modafinil will lower the extent or effect of fruquintinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid https://modafinil87653.bligblogging.com/26604111/detailed-notes-on-modafinil