Abstract Background Pain from osteoarthritis (OA) is one of the top causes of disability worldwide. but effective treatment is lacking. Nociceptive factors are released by activated synovial macrophages in OA. but depletion of synovial macrophages paradoxically worsens inflammation and tissue damage in previous studies. https://www.ngetikin.com/amazing-find-Bolia-Loop-Rug-limited-choice/