Introduction: Chronic myelomonocytic leukemia (CMML) is a clonal hematopoietic disorder that exhibits both myelodysplastic and myeloproliferative features. Progression to acute monocytic leukemia is a notable complication. especially in elderly patients. This case report describes the transformation of CMML to acute monocytic leukemia in an 84-year-old male patient. https://www.campicon.com/