Although it is unknown whether other mysterious interactions are taking place for the receptor that add to its consequences, the receptor performs a job as a unfavorable down regulator of endogenous opiate amounts through scavenging action. This drug-receptor interaction offers an alternative to manipulation of the classical opiate pathway. https://andersonzmzmu.isblog.net/detailed-notes-on-conolidine-helps-with-chronic-pain-56378917